Posts Tagged ‘Testing’

Mesothelioma Treatment to Receive Further Testing

Wednesday, March 10th, 2010

The second phase of a clinical trial testing mesothelioma treatments just commenced at Columbia University, according to news reports. The treatments being tested are to decrease signs and symptoms of peritoneal and malignant pleural mesothelioma, the two most dangerous forms of the disease.

Approximately 29 people will participate in the trial that may last up to six months.

Two of the drugs that will be tested include oxaliplatin and gemcitabine. According to TransWorldNews, oxaliplatin is “a platinum-containing organic compound which targets cancer cells by inhibiting or specifically preventing replication and repair of the cancer cells? DNA.” Oxaliplatin is from Sanofi Aventis and is manufactured as Eloxatin.

The drug is commonly used in the treatment of colon and colorectal cancers, according to news reports. Gemcitabine, which is from Eli Lilly and Company is manufactured as Gemzar. The drug, according to TransWorldNews is “a cancer drug which similarly targets the replication processes of cancer cells? DNA by inhibiting the production of the cellular material which is necessary for DNA synthesis.” Gemzar alone is used to treat patients of ovarian, lung, pancreatic and breast cancer. Combined, researchers are hoping the drugs will effectively treat and decrease mesothelioma symptoms. The Respiratory Disease Clinic in Heckeshorn in Berlin found that, “a therapy of oxapilatin and gemcitabine applied every 21 days in mesothelioma patients resulted in an increased rate of control for the disease, progression,” all of which were the results of a December 2008 study.”

Developing Mesothelioma

Mesothelioma is a deadly form of lung cancer that has been linked to the inhalation of asbestos fibers and asbestos dust. Asbestos is part of a mineral known as vermiculite that was heavily mined during the late 19th century and the early 20th century. The mineral was mined during the 1900’s until regulations were implemented.

Although, asbestos is still abundant throughout America today, according to the U.S. government. The following are possible uses:

* thermal, electrical and sound insulation

* cement

* plastic

* resins

* filtration and liquid sterilization

* friction materials

* asbestos textiles

* paper fabrication

* flooring felts

* roofing products

* pipeline wrapping

* brake and clutch pads

Garnering Mesothelioma Assistance

It is imperative for individuals who suffer from mesothelioma to receive both legal and medical assistance from knowledgeable professionals. In order to prolong signs and symptoms of the disease, individuals must seek immediate medical attention.

Also, further discussing the medical issues and legalities surrounding a mesothelioma case will improve the outcome of a mesothelioma victim. Because of the extreme dangers associated with the disease, it may be possible for a victim to receive monetary compensation. Speaking with a mesothelioma attorney will provide increased knowledge of a mesothelioma case.

LegalView (http://www.LegalView.info) provides an array of information on topics ranging from construction site accidents to automobile injuries to mesothelioma treatments, which can be found at http://mesothelioma.legalview.com.

Screening for Mesothelioma and Serum Osteopontin Level Testing ?

Thursday, March 4th, 2010


Diagnosis of malignant mesothelioma is often made too late to successfully remove the cancer or halt its progression. Consequently, researchers have been looking for a biomarker that would be definitive in diagnosing metastatic mesothelioma, but, as yet, have not been entirely successful. Serum osteopontin is a molecule whose presence is associated with metastatic mesothelioma. It one of three biomarkers that have raised a lot of interest, and generated many research studies around the world.

One study published in 2007 by the Pulmonary and Thoracic Oncology Department, Hopital Calmette (this is not a misspelling,) Lille, France concludes that osteopontin is not sufficiently specific to diagnose mesothelioma. They did conclude, however, that it might be useful in monitoring the disease. The paper states that cytohistology is still the most accurate diagnostic measure for mesothelioma.

A study published by the Department of Surgery, Wayne State University, Karmanos Cancer Institute, John A. Dingell Veterans Hospital, Detroit, MI noted that the serum osteopontin levels measured notably higher in pleural mesothelioma patients, as compared to a group whose participants had been exposed to asbestos and had various asbestos-related diseases (plaques, fibrosis or both, but not mesothelioma.) Their conclusion was that serum osteopontin levels are useful for distinguishing between patients who have pleural mesothelioma and those that have other asbestos related diseases that are not cancerous.

A study by doctors at Institut National de la Sante et de la Recherche Medicale (INSERM) U774, Institut Pasteur de Lille, Lille, France studied both the diagnostic and prognostic value of osteopontin with slightly different results than other studies revealed. They concluded that osteopontin is less accurate as a diagnostic measure, but may have potential as a prognostic marker.

In a fourth study by doctors at the National Research Centre for Asbestos Related Diseases, Western Australian Institute of Medical Research, Nedlands, Australia similar results show that osteopontin is not the marker scientists hope to find. This report added that osteopontin levels did not differentiate between mesothelioma and other malignancies.

Most other studies seem to confirm these results, and each points to two other biomarkers as having the potential to provide differential diagnosis reliability. Of the three, soluble mesothelin-related peptide (SMRP) shows the most promise for both early detection of malignant mesothelioma and differentiating between benign and metastatic carcinomas.

Treatment for mesothelioma can be expensive, and impose great demands on you and your family. If you have been diagnosed with an asbestos-related disease, you may be entitled to a settlement to pay these expenses. Please contact the lawyers experienced in mesothelioma claims in Baltimore, Maryland and Washington, D.C.